The aim of this study is to examine the relationship between the information literacy levels and entrepreneurship levels of students studying at the faculty of sports sciences. The study employed the relational screening model, a general scanning model. The population of our study consists of İnönü, Fırat, Bingöl, and Munzur Universities located in the provinces of Malatya, Elazığ, Bingöl, and Tunceli in the TRB1 Region. Its sample consists of a total of 461 (157 women, 307 men) students participating in the study from the faculties of sports sciences at these universities. We used the Kruskal-Wallis and Mann-Whitney U tests with a significance level of 0.05 to look for differences in the mean levels of information literacy and how each person saw themselves as an entrepreneur. We used Spearman Brown Rank Correlation Analysis at the 0.05 significance level to determine whether there is a relationship between the variables. We conducted a regression analysis at the 0.05 significance level to determine the effect of the detected relationship between the variables. As a result of the research, it was found that the entrepreneurship levels of the sports sciences faculty students from four universities were at a medium level, while their information literacy levels were at a good level, and a positive relationship was identified between them. We found a positive relationship between the sub-dimensions of information literacy levels and entrepreneurship levels of sports sciences faculty students. The sub-dimension of information access level showed the highest correlation. This situation suggests that we can use students' access to information as a parameter to enhance their entrepreneurship levels. Therefore, higher education institutions should develop information literacy and entrepreneurship standards that take into account local needs.