1
Ondokuz Mayıs University, Yaşar Doğu Faculty of Sport Sciences, Samsun, Turkiye
2
Ondokuz Mayıs University, Yaşar Doğu Faculty of Sport Sciences, Samsun, Turkiye
Abstract
This study aimed to investigate the relationship between the SLC6A4 gene’s 5-HTTLPR polymorphism and aggression levels among elite combat athletes. A total of 40 male athletes from taekwondo (N=10), kickboxing (N=10), boxing (N=10) and wrestling (N=10), aged between 20-35 years, participated in the study. The quantitative data was collected by using a personal information form and the Aggression Scale Inventory. Whole blood samples were taken for DNA isolation and genotyping analysis was performed. In 5-HTTLPR polymorphism, 38.8% (31) had the L allele and 61.3% (49) had the S allele. The highest S allele distribution in 5-HTTLPR polymorphism was found in taekwondo branch (32.7%). In 5-HTTLPR polymorphism, 77.5% (31) and 9% (22.5%) of the athletes had L/S and S/S genotyping, respectively. According to the aggression scale inventory, it was found that the wrestling branch had the highest general aggression mean (114.60), however; there was no significant difference between the sub-dimensions of aggression (Destructive, Attemptive and Passive) in branch comparisons (p>0.05). Based on the applied aggression scale inventory and genetic analysis of SLC6A4 gene 5-HTTLPR polymorphism, it can be considered that the combat athletes participating in the study are tend to aggression.
Bilen, E., & Elioz, M. (2023). The relationship between the SLC6A4 gene polymorphism (rs 5-HTTLPR) and aggression in combat athletes. Journal of ROL Sport Sciences, 4(4), 1423–1436. https://doi.org/10.5281/zenodo.10377634
📄Ateş, Ö., Çorak, A., Kulaksız, H., Sercan, C., Kapıcı, S., Yüksel, İ., … et al. (2017). Sağlıklı türk genç futbolcularda anksiyete ile ilişkili SLC6A4 geni promoter “s” ve “l” alellerinin saptanması. The Journal Of Neurobehavioral Sciences, 4(3), 95-98.
📄Brown, D. R., Wang, Y., Ward, A., Ebbeling, C. B., Fortlage, L., Puleo, E., … et al. (1995). Chronic psychological effects of exercise and exercise plus cognitive strategies. Medicine and Science in Sports and Exercise, 27(5), 765-775.
📄Bulgay, C., Kasakolu, A., Kazan, H. H., Mijaica, R., Zorba, E., Akman, O., … et al. (2023). Exome-wide association study of competitive performance in elite athletes. Genes, 14(3), 660.
📄Butovskaya, P. R., Butovskaya, M. L., Vasilyev, V. A., Lazebny, O. E., Shibalev, D. V., Veselovskaya, … et al. (2013). Molecular-genetic polymorphisms of dopamine, serotonin and androgenic systems as molecular markers of success in judo wrestling sportsmen. Journal of Bioanalysis and Biomedicine, 5(S3), 2-6.
📄Carlström, E. L., Saetre, P., Rosengren, A., Thygesen, J. H., Djurovic, S., Melle, I., … et al. (2012). Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia. Behavioral and Brain Functions, 8(1),1-8.
📄Ceylan, L., & Eliöz, M. (2022). Sporcularda SLC6A4 geni ve saldırganlık. Gazi Kitapevi.
📄Çam, F. S., Çolakoğlu, M., Tok, S., Tok, İ., Kutlu, N., & Berdeli, A. (2010). Personality traits and DRD4, DAT1,5-HT2A gene polymorphisms in risky and non risky sports participation. Turkiye Klinikleri, 30(5), 1459-64.
📄Çelik, F. H., & Hocaoğlu, Ç. (2016). Major depresif bozukluk tanımı, etyolojisi ve epidemiyolojisi: bir gözden geçirme. Journal of Contemporary Medicine, 6(1), 51-66.
📄Demir, P., & Çelebi, M. (2019). Spor bilimleri fakültesinde eğitim gören mücadele sporcularının zihinsel dayanıklılıklarının incelenmesi. International Journal of Contemporary Educational Studies, 5(2), 188-199.
📄Dervent, F., Arslanoğlu, E., & Şenel, Ö. (2010). Lise öğrencilerinin saldırganlık düzeyleri ve sportif aktivitelere katılımla ilişkisi (İstanbul ili örneği). Uluslararası İnsan Bilimleri Dergisi, 7(1), 521-533.
📄Eken, B. F., Akpınaroğlu, C., Arslan, K. S., Sercan, C., & Ulucan, K. (2018). Genlerin sporda psikolojik faktörlerle ilişkisi. The Journal Of Neurobehavioral Sciences, 5(1), 56-61.
📄Eken, B. F., Polat, T., Aslan, B. T., Ulucan, K., Doğan, C. S., & Oktay Ş. (2021). Futbolcularda SLC6A4 promotör polimorfizminin dağılımı. Spor ve Performans Araştırmaları Dergisi, 12(3), 212-22.
📄Erdal, E. M., Herken, H., Barlas, Ö., & Erdal, N. (2000). Serotonin transporter gen polimorfizmi. Klinik Psikiyatri, (3), 192-196.
📄Erdoğdu, M., Koçyiğit, M., Kayışoğlu, N. B., & Yılmaz, B. (2018). Futbol ve futsal branşlarında spor yapan genç kadınların saldırganlık yaklaşımları. International Journal of Cultural and Social Studies, 4(3), 1-14.
📄Ersoy, A., Tazegül, Ü., & Sancaklı, H. (2012). Güreşçilerin saldırganlık düzeylerinin sosyo-demografik açıdan incelenmesi (Ankara Örneği). Uluslararası İnsan Bilimleri Dergisi, 9(1), 385-397.
📄Filonzi, L., Franchini, N., Vaghi, M., Chiesa, S., & Marzano, N. F. (2015). The potential role of myostatin and neurotransmission genes in elite sport performances. Journal of Biosciences, (40), 531-537.
📄Fox E., Ridgewell, A., & Ashwin, C. (2009). Looking on the bright side: biased attention and the human serotonin transporter gene. Proceedings of the Royal Society B: Biological Sciences, 276(1663), 1747-1751.
📄Gerra, G., Garofano, L., Castaldini, L., Rovetto, F., Zaimovic, A., Moi, … et al. (2005). Serotonin transporter promoter polymorphism genotype is associated with temperament, personality traits and illegal drugs use among adolescents. Journal of Neural Transmission, (112), 1397–1410.
📄Golby, J., & Sheard, M. (2006). The relationship between genotype and positive psychological development in national-level swimmers. European Psychologist, 11(2),143-148.
📄Gronek, P., Wieliński, D., & Gronek, J. (2015). Genetic and non-genetic determinants of aggression in combat sports. Open Life Sciences, 10(1), 7-18.
📄Güvendi, B., & Türksoy-Işım, A. (2019). Moral disengagement and aggression in fight sport athletes. Journal of Education and Training Studies,7(7), 118-123.
📄Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D., … et al. (1996). Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry, 66(6), 2621-2624.
📄Hernandez, J., & Anderson, K .B. (2015). Internal combat sports training and the reduction of hostility and aggression in combat sports students. Psi Chi Journal of Psychological Research, 20(3),169-176.
📄Josephs, R, A., Telch, M. J., Hixon, G., Evans, J. J., Lee, H., Knopik, V. S., … et al. (2013). Genetic and hormonal sensitivity to threat: testing a serotonin transporter genotype×testosterone interaction. Psychoneuroendocrinology, 37(6),752–761.
📄Lesch, K. P., & Mössner, R. (1998). Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?. Biological Psychiatry, 44(3),179-192.
📄Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., … et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274(5292), 1527-1531.
📄Levinson, D. F. (2006). The genetics of depression: a review. Biol Psychiatry, 60(2), 84-92.
📄Madden, M. E. (1990). Attributions of control and vulnerability at the beginning and end of a karate course. Perceptual and Motor Skills, 70(3), 787-794.
📄Özerkan, K. N. (2004). Spor psikolojisine giriş. Nobel Yayınları.
📄Petito, A., Altamura, M., Luso, S., Padalino, F. A., Sessa, F., D’Andrea, G., … et al. (2016). The relationship between personality traits,the 5htt polymorphisms, and the occurrence of anxiety and depressive symptoms in elite athletes. Plos One, 11(6), 1-13.
📄Ramamoorthy, S., Bauman, A. L., Moore, K. R., Han, H., Yang-Feng, T., Chang, A. S., … et al. (1993). Antidepressant and cocaine sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proceedings of the National Academy of Sciences, 90(6), 2542-2546.
📄Sanhueza, J. A., Zambrano, T., Bahamondes-Avila, C., & Salazar, L.A. (2016). Association of anxiety-related polymorphisms with sports performance in chilean long distance triathletes: a pilot study. Journal of Sports Science and Medicine, 15(4),554-561.
📄Saunders, C. J., Milander, L., Hew-Butler, T., Xenophontos, S. L., Cariolou, M. A., Anastassiades, L. C., … et al. (2006). Dipsogenic genes associated with weight changes during ironman triathlons. Human Molecular Genetics, 15(20), 2980-2987.
📄Sysoeva, O. V., Maluchenko, N. V., Timofeeva, M. A., Portnova, G. V., Kulikova, M. A., Tonevitsky, A. G., … et al. (2009). Agression and 5HTT polymorphism in females: study of synchronized swimming and control groups. International Journal of Psychophysiology, 72(2),173-178.
📄Tekin, A., Tekin, G., & Eliöz, M. (2011). Kick-Boksörlerin çeşitli değişkenlere göre öfke ve saldırganlık düzeylerinin araştırılması. Türkiye Kickboks Federasyonu Spor Bilimleri Dergisi, 4(1),34-48.
📄Trushkin, E. V., Timofeeva, M. A., Sysoeva, O. V., Davydov, Y. I., Knicker, A., Struder, H., … et al. (2011). Association of SLC6A4 Gene 5-HTTLPR polymorphism with parameters of simple and complex reaction times and critical flicker frequency threshold in athletes during exhaustive exercise. Sports Medicine, (150), 471-474.
📄Tutkun, E., Güner, B. Ç., Ağaoğlu, S. A., & Soslu, R. (2010). Takım sporları ve bireysel sporlar yapan sporcuların saldırganlık düzeylerinin değerlendirilmesi. Spor ve Performans Araştırmaları Dergisi, 1(1), 23-29.
📄Ulucan, K., Sercan, C., & Bıyıklı, T. (2015). Distribution of angiotensin-1 converting enzyme insertion/deletion and α-actinin-3 codon 577 polymorphisms in turkish male soccer players. Genetics and epiGenetics, (7), 1-4.
📄Ulucan, K., Topal, E. S., Aksulu, B. K., Yaman, B., Çiftci, İ. C., & Bıyıklı, T. (2015). Atletik performans, genetik ve gen dopingi. İstanbul Kanuni Sultan Süleyman Tıp Dergisi, 7(2), 58-62.
📄Ulucan, K., Yalçın, S., Akbaş, B., Uyumaz, F., & Konuk, M. (2014). Analysis of solute carrier family 6 member 4 gene promoter polymorphism in young turkish basketball players. The Journal Of Neurobehavıoral Sciences (1), 37-40.
📄Weinberg, R. S., & Gould, D. (2015). Spor ve egzersiz psikolojisinin temelleri. Nobel Akademik Yayıncılık.
📄Yiğit, S., Polat, T., Doğan, C. S., Tunalı, S., Ekmekci, R., & Ulucan, K. (2020). Determination of SLC6A4 promoter L/S polymorphism in professional volleyball players and comparison of the literature. The Journal of Neurobehavioral Sciences, 7(2), 66.