Open Access

The relationship between the SLC6A4 gene polymorphism (rs 5-HTTLPR) and aggression in combat athletes

1 Ondokuz Mayıs University, Yaşar Doğu Faculty of Sport Sciences, Samsun, Turkiye
2 Ondokuz Mayıs University, Yaşar Doğu Faculty of Sport Sciences, Samsun, Turkiye

Abstract

This study aimed to investigate the relationship between the SLC6A4 gene’s 5-HTTLPR polymorphism and aggression levels among elite combat athletes. A total of 40 male athletes from taekwondo (N=10), kickboxing (N=10), boxing (N=10) and wrestling (N=10), aged between 20-35 years, participated in the study. The quantitative data was collected by using a personal information form and the Aggression Scale Inventory. Whole blood samples were taken for DNA isolation and genotyping analysis was performed. In 5-HTTLPR polymorphism, 38.8% (31) had the L allele and 61.3% (49) had the S allele. The highest S allele distribution in 5-HTTLPR polymorphism was found in taekwondo branch (32.7%). In 5-HTTLPR polymorphism, 77.5% (31) and 9% (22.5%) of the athletes had L/S and S/S genotyping, respectively. According to the aggression scale inventory, it was found that the wrestling branch had the highest general aggression mean (114.60), however; there was no significant difference between the sub-dimensions of aggression (Destructive, Attemptive and Passive) in branch comparisons (p>0.05). Based on the applied aggression scale inventory and genetic analysis of SLC6A4 gene 5-HTTLPR polymorphism, it can be considered that the combat athletes participating in the study are tend to aggression.

Keywords

How to Cite

Bilen, E., & Elioz, M. (2023). The relationship between the SLC6A4 gene polymorphism (rs 5-HTTLPR) and aggression in combat athletes. Journal of ROL Sport Sciences, 4(4), 1423–1436. https://doi.org/10.5281/zenodo.10377634

References

📄 Ateş, Ö., Çorak, A., Kulaksız, H., Sercan, C., Kapıcı, S., Yüksel, İ., … et al. (2017). Sağlıklı türk genç futbolcularda anksiyete ile ilişkili SLC6A4 geni promoter “s” ve “l” alellerinin saptanması. The Journal Of Neurobehavioral Sciences, 4(3), 95-98.
📄 Brown, D. R., Wang, Y., Ward, A., Ebbeling, C. B., Fortlage, L., Puleo, E., … et al. (1995). Chronic psychological effects of exercise and exercise plus cognitive strategies. Medicine and Science in Sports and Exercise, 27(5), 765-775.
📄 Bulgay, C., Kasakolu, A., Kazan, H. H., Mijaica, R., Zorba, E., Akman, O., … et al. (2023). Exome-wide association study of competitive performance in elite athletes. Genes, 14(3), 660.
📄 Butovskaya, P. R., Butovskaya, M. L., Vasilyev, V. A., Lazebny, O. E., Shibalev, D. V., Veselovskaya, … et al. (2013). Molecular-genetic polymorphisms of dopamine, serotonin and androgenic systems as molecular markers of success in judo wrestling sportsmen. Journal of Bioanalysis and Biomedicine, 5(S3), 2-6.
📄 Carlström, E. L., Saetre, P., Rosengren, A., Thygesen, J. H., Djurovic, S., Melle, I., … et al. (2012). Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia. Behavioral and Brain Functions, 8(1),1-8.